Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer

AbstractContext Danggui Buxue Decoction (DBD), a traditional Chinese medicine formula, has the potential to enhance the antitumor effect of gemcitabine in non-small cell lung cancer (NSCLC) treatment by increasing gemcitabine's active metabolites. However, whether gemcitabine affects the pharma...

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Main Authors: Xin Xu (Author), Xi-yang Sun (Author), Ming Chang (Author), Zhao-liang Hu (Author), Ting-ting Cheng (Author), Tai-jun Hang (Author), Min Song (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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