Increased myocellular lipid and IGFBP‐3 expression in a pre‐clinical model of pancreatic cancer‐related skeletal muscle wasting

• Main Authors: Calvin L. Cole (Author), John F. Bachman (Author), Jian Ye (Author), Joseph Murphy (Author), Scott A. Gerber (Author), Christopher A. Beck (Author), Brendan F. Boyce (Author), Gowrishankar Muthukrishnan (Author), Joe V. Chakkalakal (Author), Edward M. Schwarz (Author), David Linehan (Author)
• Format: Book
• Published: Wiley, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Skeletal muscle wasting (SMW) in cancer patients is associated with increased morbidity, mortality, treatment intolerance and discontinuation, and poor quality of life. This is particularly true for patients with pancreatic ductal adenocarcinoma (PDAC), as over 85% experience SMW...