Cardiac NF-κB Acetylation Increases While Nrf2-Related Gene Expression and Mitochondrial Activity Are Impaired during the Progression of Diabetes in UCD-T2DM Rats

• Main Authors: Max A. Thorwald (Author), Jose A. Godoy-Lugo (Author), Ruben Rodriguez (Author), Kimber L. Stanhope (Author), James L. Graham (Author), Peter J. Havel (Author), Henry Jay Forman (Author), Rudy M. Ortiz (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The onset of type II diabetes increases the heart's susceptibility to oxidative damage because of the associated inflammation and diminished antioxidant response. Transcription factor NF-κB initiates inflammation while Nrf2 controls antioxidant defense. Current evidence suggests crosstalk betwe...