Cardiac NF-κB Acetylation Increases While Nrf2-Related Gene Expression and Mitochondrial Activity Are Impaired during the Progression of Diabetes in UCD-T2DM Rats

• Auteurs principaux: Max A. Thorwald (Auteur), Jose A. Godoy-Lugo (Auteur), Ruben Rodriguez (Auteur), Kimber L. Stanhope (Auteur), James L. Graham (Auteur), Peter J. Havel (Auteur), Henry Jay Forman (Auteur), Rudy M. Ortiz (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The onset of type II diabetes increases the heart's susceptibility to oxidative damage because of the associated inflammation and diminished antioxidant response. Transcription factor NF-κB initiates inflammation while Nrf2 controls antioxidant defense. Current evidence suggests crosstalk betwe...