Serotonin Potentiates High-Glucose-Induced Endothelial Injury: the Role of Serotonin and 5-HT2A Receptors in Promoting Thrombosis in Diabetes

To clarify the involvement of 5-hydroxytryptamine (5-HT) in promotion of thrombogenesis in diabetes, we examined the inhibitory effect of sarpogrelate, a 5-HT2A receptor antagonist, on thrombus formation in diabetic rats. In streptozotocin-induced diabetic rats, polyethylene tube-induced thrombus fo...

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Main Authors: Kumi Yamada (Author), Hisae Niki (Author), Hitoshi Nagai (Author), Masakuni Nishikawa (Author), Haruto Nakagawa (Author)
Formato: Livro
Publicado em: Elsevier, 2012-01-01T00:00:00Z.
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