Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Membrane Environment-Contributions of Polar and Non-Polar Interactions

• Main Authors: Maria João Moreno (Author), Hugo A. L. Filipe (Author), Susana V. P. Cunha (Author), Cristiana V. Ramos (Author), Patrícia A. T. Martins (Author), Biebele Abel (Author), Luís M. S. Loura (Author), Suresh V. Ambudkar (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The transport of drugs by efflux transporters in biomembranes limits their bioavailability and is a major determinant of drug resistance development by cancer cells and pathogens. A large number of chemically dissimilar drugs are transported, and despite extensive studies, the molecular determinants...