Structural Bioinformatics and Protein Docking Analysis of the Molecular Chaperone-Kinase Interactions: Towards Allosteric Inhibition of Protein Kinases by Targeting the Hsp90-Cdc37 Chaperone Machinery

• Hoofdauteurs: Gennady Verkhivker (Auteur), Elizabeth Berrigan (Auteur), Nathan Lawless (Auteur), Kristin Blacklock (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2013-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

A fundamental role of the Hsp90-Cdc37 chaperone system in mediating maturation of protein kinase clients and supporting kinase functional activity is essential for the integrity and viability of signaling pathways involved in cell cycle control and organism development. Despite significant advances...