Novel Pyrrole Derivatives as Multi-Target Agents for the Treatment of Alzheimer's Disease: Microwave-Assisted Synthesis, In Silico Studies and Biological Evaluation

• Main Authors: Emilio Mateev (Author), Valentin Karatchobanov (Author), Marjano Dedja (Author), Konstantinos Diamantakos (Author), Alexandrina Mateeva (Author), Muhammed Tilahun Muhammed (Author), Ali Irfan (Author), Magdalena Kondeva-Burdina (Author), Iva Valkova (Author), Maya Georgieva (Author), Alexander Zlatkov (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Considering the complex pathogenesis of Alzheimer's disease (AD), the multi-target ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, one novel pyrrole-based hydrazide (<b>vh0</b>...