Blocking TRAIL-DR5 signaling pathway with soluble death receptor 5 fusion protein mitigates radiation-induced injury

• Main Authors: Danyang Zhao (Author), Lei Yang (Author), Peng Han (Author), Haihui Zhang (Author), Fanjun Wang (Author), Zhiyun Meng (Author), Hui Gan (Author), Zhuona Wu (Author), Wenzhong Sun (Author), Chuan Chen (Author), Guifang Dou (Author), Ruolan Gu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The increasing application of nuclear technology, the high fatality of acute radiation syndrome (ARS) and its complex mechanism make ARS a global difficulty that requires urgent attention. Here we reported that the death receptor 5 (DR5), as well as its ligand tumor necrosis factor-related apoptosis...