A simple method to improve the dissolution of repaglinide and exploration of its mechanism

• Main Authors: Zhaolu Zhu (Author), Tianzhi Yang (Author), Yanan Zhao (Author), Nannan Gao (Author), Donglei Leng (Author), Pingtian Ding (Author)
• Format: Book
• Published: Elsevier, 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, a simple and rapid method was developed to improve the in vitro dissolution of repaglinide, an oral antidiabetic drug, which was based on addition of meglumine in 50% (v/v) ethanol to dissolve repaglinide, and the drug dissolved in meglumine/50% ethanol was used directly with a...