DNA methyltransferase inhibitor exposure-response: Challenges and opportunities

• Main Authors: Amanda B. Kagan (Author), Dominique A. Garrison (Author), Nicole M. Anders (Author), Jonathan A. Webster (Author), Sharyn D. Baker (Author), Srinivasan Yegnasubramanian (Author), Michelle A. Rudek (Author)
• Format: Book
• Published: Wiley, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although DNA methyltransferase inhibitors (DNMTis), such as azacitidine and decitabine, are used extensively in the treatment of myelodysplastic syndromes and acute myeloid leukemia, there remain unanswered questions about DNMTi's mechanism of action and predictors of clinical response...