Conventional Anti-glioblastoma Chemotherapy Affects Proteoglycan Composition of Brain Extracellular Matrix in Rat Experimental Model in vivo

• Main Authors: Alexandra Y. Tsidulko (Author), Cynthia Bezier (Author), Gabin de La Bourdonnaye (Author), Anastasia V. Suhovskih (Author), Tatiana M. Pankova (Author), Galina M. Kazanskaya (Author), Svetlana V. Aidagulova (Author), Elvira V. Grigorieva (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Temozolomide (TMZ) is a conventional chemotherapy drug for adjuvant treatment of glioblastoma multiforme (GBM), often accompanied by dexamethasone (DXM) to prevent brain oedema and alleviate clinical side effects. Here, we aimed to investigate an ability of the drugs to affect normal brain tissue in...