Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development

• Κύριοι συγγραφείς: Sherry Zhao (Συγγραφέας), Mary Gockenbach (Συγγραφέας), Manuela Grimstein (Συγγραφέας), Hari Cheryl Sachs (Συγγραφέας), Mark Mirochnick (Συγγραφέας), Kimberly Struble (Συγγραφέας), Yodit Belew (Συγγραφέας), Jian Wang (Συγγραφέας), Edmund V. Capparelli (Συγγραφέας), Brookie M. Best (Συγγραφέας), Tamara Johnson (Συγγραφέας), Jeremiah D. Momper (Συγγραφέας), Anil R. Maharaj (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Background: Alterations in plasma protein concentrations in pregnant and postpartum individuals can influence antiretroviral (ARV) pharmacokinetics. Physiologically-based pharmacokinetic (PBPK) models can serve to inform drug dosing decisions in understudied populations. However, development of such...