Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development

• Main Authors: Sherry Zhao (Author), Mary Gockenbach (Author), Manuela Grimstein (Author), Hari Cheryl Sachs (Author), Mark Mirochnick (Author), Kimberly Struble (Author), Yodit Belew (Author), Jian Wang (Author), Edmund V. Capparelli (Author), Brookie M. Best (Author), Tamara Johnson (Author), Jeremiah D. Momper (Author), Anil R. Maharaj (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Alterations in plasma protein concentrations in pregnant and postpartum individuals can influence antiretroviral (ARV) pharmacokinetics. Physiologically-based pharmacokinetic (PBPK) models can serve to inform drug dosing decisions in understudied populations. However, development of such...