Recombinant paracoccin reproduces the biological properties of the native protein and induces protective Th1 immunity against Paracoccidioides brasiliensis infection.

• Main Authors: Ana Claudia Paiva Alegre (Author), Aline Ferreira Oliveira (Author), Fausto Bruno Dos Reis Almeida (Author), Maria Cristina Roque-Barreira (Author), Ebert Seixas Hanna (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Paracoccin is a dual-function protein of the yeast Paracoccidioides brasiliensis that has lectin properties and N-acetylglucosaminidase activities. Proteomic analysis of a paracoccin preparation from P. brasiliensis revealed that the sequence matched that of the hypothetical protein enco...