Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA

• Autores principales: Richard Grondin (Autor), Pei Ge (Autor), Qingmin Chen (Autor), Jessica E Sutherland (Autor), Zhiming Zhang (Autor), Don M Gash (Autor), David K Stiles (Autor), Gregory R Stewart (Autor), Dinah W Y Sah (Autor), William F Kaemmerer (Autor)
• Formato: Libro
• Publicado: Elsevier, 2015-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression of huntingtin mRNA achievable with short infus...