Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA

• Main Authors: Richard Grondin (Author), Pei Ge (Author), Qingmin Chen (Author), Jessica E Sutherland (Author), Zhiming Zhang (Author), Don M Gash (Author), David K Stiles (Author), Gregory R Stewart (Author), Dinah W Y Sah (Author), William F Kaemmerer (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression of huntingtin mRNA achievable with short infus...