Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA

• Váldodahkkit: Richard Grondin (Dahkki), Pei Ge (Dahkki), Qingmin Chen (Dahkki), Jessica E Sutherland (Dahkki), Zhiming Zhang (Dahkki), Don M Gash (Dahkki), David K Stiles (Dahkki), Gregory R Stewart (Dahkki), Dinah W Y Sah (Dahkki), William F Kaemmerer (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2015-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression of huntingtin mRNA achievable with short infus...