In vitro and in vivo assessment of hydroxypropyl cellulose as functional additive for enabling formulations containing itraconazole

• Main Authors: Rafael D. Bachmaier (Author), Marius Monschke (Author), Thilo Faber (Author), Anna K. Krome (Author), Yann Pellequer (Author), Edmont Stoyanov (Author), Alf Lamprecht (Author), Karl G. Wagner (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Using polymers as additives to formulate ternary amorphous solid dispersions (ASDs) has successfully been established to increase the bioavailability of poorly soluble drugs, when one polymer is not able to provide both, stabilizing the drug in the matrix and the supersaturated solution. Therefore,...