Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα

• Main Authors: Zhenhua Wu (Author), Yunpeng Bai (Author), Yujuan Qi (Author), Chao Chang (Author), Yan Jiao (Author), Yaobang Bai (Author), Zhigang Guo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractContext Metformin (Met) has a protective effect against cardiac ischemia and reperfusion (I/R) injury.Objective This study uncovered the Met effect on ferroptosis in cardiac I/R.Materials and methods Sprague-Dawley rats underwent cardiac I/R treatment (ischaemia 30 min; reperfusion 24 h) (I/...