Pharmacological Characterization of the Newly Synthesized Nociceptin/Orphanin FQ-Receptor Agonist 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R )-3-piperidinyl]-1H-benzimidazole as an Anxiolytic Agent

• Main Authors: Akiko Hirao (Author), Aki Imai (Author), Yutaka Sugie (Author), Yoshinari Yamada (Author), Shigeo Hayashi (Author), Katsuo Toide (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nociceptin/orphanin FQ peptide (NOP)-receptor agonists have been shown to produce anxiolytic-like effects in rodents subjected to various behavioral assays. Recently, we developed a new nonpeptide agonist of the NOP receptor, 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimi...