Pharmacological Characterization of the Newly Synthesized Nociceptin/Orphanin FQ-Receptor Agonist 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R )-3-piperidinyl]-1H-benzimidazole as an Anxiolytic Agent

Pharmacological Characterization of the Newly Synthesized Nociceptin/Orphanin FQ-Receptor Agonist 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R )-3-piperidinyl]-1H-benzimidazole as an Anxiolytic Agent

Nociceptin/orphanin FQ peptide (NOP)-receptor agonists have been shown to produce anxiolytic-like effects in rodents subjected to various behavioral assays. Recently, we developed a new nonpeptide agonist of the NOP receptor, 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimi...

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Main Authors: Akiko Hirao (Author), Aki Imai (Author), Yutaka Sugie (Author), Yoshinari Yamada (Author), Shigeo Hayashi (Author), Katsuo Toide (Author)
Format: Book
Published: Elsevier, 2008-01-01T00:00:00Z.
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