LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

• المؤلفون الرئيسيون: Weiwei Ge (مؤلف), Qiaohua Hu (مؤلف), Xiangshao Fang (مؤلف), Juanhua Liu (مؤلف), Jing Xu (مؤلف), Juntao Hu (مؤلف), Xuefen Liu (مؤلف), Qin Ling (مؤلف), Yue Wang (مؤلف), He Li (مؤلف), Ming Gao (مؤلف), Longyuan Jiang (مؤلف), Zhengfei Yang (مؤلف), Wanchun Tang (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2019-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe...