LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

• প্রধান লেখক: Weiwei Ge (লেখক), Qiaohua Hu (লেখক), Xiangshao Fang (লেখক), Juanhua Liu (লেখক), Jing Xu (লেখক), Juntao Hu (লেখক), Xuefen Liu (লেখক), Qin Ling (লেখক), Yue Wang (লেখক), He Li (লেখক), Ming Gao (লেখক), Longyuan Jiang (লেখক), Zhengfei Yang (লেখক), Wanchun Tang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2019-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe...