LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

• मुख्य लेखकों: Weiwei Ge (लेखक), Qiaohua Hu (लेखक), Xiangshao Fang (लेखक), Juanhua Liu (लेखक), Jing Xu (लेखक), Juntao Hu (लेखक), Xuefen Liu (लेखक), Qin Ling (लेखक), Yue Wang (लेखक), He Li (लेखक), Ming Gao (लेखक), Longyuan Jiang (लेखक), Zhengfei Yang (लेखक), Wanchun Tang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2019-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe...