Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound

• Автори: Emilee E. Colón-Lorenzo (Автор), Daisy D. Colón-López (Автор), Joel Vega-Rodríguez (Автор), Alice Dupin (Автор), David A. Fidock (Автор), Abel Baerga-Ortiz (Автор), José G. Ortiz (Автор), Jürgen Bosch (Автор), Adelfa E. Serrano (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Plasmodium falciparum parasites are increasingly drug-resistant, requiring the search for novel antimalarials with distinct modes of action. Enzymes in the glutathione pathway, including glutathione S-transferase (GST), show promise as novel antimalarial targets. This study aims to better understand...