Design, synthesis, characterization, antimicrobial activity, cytotoxicity, molecular docking, and in-silico ADMET analysis of the novel cefuroxime derivatives

• Main Authors: Ananta Kumar Das (Author), Prosenjit Paul (Author), Mahian Parveg Pranto (Author), Md. Jahid Hassan (Author), Koushik Saha (Author), Md. Emdad Hossain (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This research aims to design and synthesize novel derivatives of Cefuroxime to evaluate their antibacterial effectiveness in comparison to Cefuroxime and to decrease resistance.Schotten Baumann's reaction synthesizes anhydride from acyl chlorides and carboxylate anion. Cefuroxime sodium was rea...