Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

• Main Authors: Adam R. Root (Author), Gurkan Guntas (Author), Madan Katragadda (Author), James R. Apgar (Author), Jatin Narula (Author), Chew Shun Chang (Author), Sara Hanscom (Author), Matthew McKenna (Author), Jason Wade (Author), Caryl Meade (Author), Weijun Ma (Author), Yongjing Guo (Author), Yan Liu (Author), Weili Duan (Author), Claire Hendershot (Author), Amy C. King (Author), Yan Zhang (Author), Eric Sousa (Author), Amy Tam (Author), Susan Benard (Author), Han Yang (Author), Kerry Kelleher (Author), Fang Jin (Author), Nicole Piche-Nicholas (Author), Sinead E. Keating (Author), Fernando Narciandi (Author), Rosemary Lawrence-Henderson (Author), Maya Arai (Author), Wayne R. Stochaj (Author), Kristine Svenson (Author), Lidia Mosyak (Author), Khetemcnee Lam (Author), Christopher Francis (Author), Kimberly Marquette (Author), Liliana Wroblewska (Author), H. Lily Zhu (Author), Alfredo Darmanin Sheehan (Author), Edward R. LaVallie (Author), Aaron M. D'Antona (Author), Alison Betts (Author), Lindsay King (Author), Edward Rosfjord (Author), Orla Cunningham (Author), Laura Lin (Author), Puja Sapra (Author), Lioudmila Tchistiakova (Author), Divya Mathur (Author), Laird Bloom (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage display and rational design protein engineering, we have developed a fully humanized and manufacturable C...