CHF6001 Inhibits NF-κB Activation and Neutrophilic Recruitment in LPS-Induced Lung Inflammation in Mice

• Egile Nagusiak: Fabio F. Stellari (Egilea), Angelo Sala (Egilea), Francesca Ruscitti (Egilea), Carola Buccellati (Egilea), Andrew Allen (Egilea), Patrizia Risé (Egilea), Maurizio Civelli (Egilea), Gino Villetti (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Inhibitors of phosphodiesterase 4 (PDE4) are potent anti-inflammatory agents, inhibiting the production of inflammatory mediators through the elevation of intracellular cAMP concentrations. We studied the activity of a novel PDE4 inhibitor, CHF6001, both in vitro in human cells and in vivo, using bi...