CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells

• Main Authors: Soona Shin (Author), John Le Lay (Author), Logan J. Everett (Author), Rana Gupta (Author), Kiran Rafiq (Author), Klaus H. Kaestner (Author)
• Format: Book
• Published: Elsevier, 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon-like peptide-1 (GLP-1) plays a major role in pancreatic β-cell function and survival by increasing cytoplasmic cAMP levels, which are thought to affect transcription through activation of the basic leucine zipper (bZIP) transcription factor CREB. Here, we test CREB function in th...