De Novo Synthesis of Elastin by Exogenous Delivery of Synthetic Modified mRNA into Skin and Elastin-Deficient Cells

• Main Authors: Mario Lescan (Author), Regine Mariette Perl (Author), Sonia Golombek (Author), Martin Pilz (Author), Ludmilla Hann (Author), Mahua Yasmin (Author), Andreas Behring (Author), Timea Keller (Author), Andrea Nolte (Author), Franziska Gruhn (Author), Efrat Kochba (Author), Yotam Levin (Author), Christian Schlensak (Author), Hans Peter Wendel (Author), Meltem Avci-Adali (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elastin is one of the most important and abundant extracellular matrix (ECM) proteins that provide elasticity and resilience to tissues and organs, including vascular walls, ligaments, skin, and lung. Besides hereditary diseases, such as Williams-Beuren syndrome (WBS), which results in reduced elast...