Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation
AbstractAbnormal accumulation of branched-chain amino acids (BCAAs) can lead to metabolic diseases and cancers. Branched-chain α-keto acid dehydrogenase kinase (BCKDK) is a key negative regulator of BCAA catabolism, and targeting BCKDK provides a promising therapeutic approach for diseases caused by...
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Taylor & Francis Group,
2024-12-01T00:00:00Z.
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