Endothelial NOX5 Obliterates the Reno-Protective Effect of Nox4 Deletion by Promoting Renal Fibrosis via Activation of EMT and ROS-Sensitive Pathways in Diabetes

• Main Authors: Karin A. M. Jandeleit-Dahm (Author), Haritha R. Kankanamalage (Author), Aozhi Dai (Author), Jaroslawna Meister (Author), Sara Lopez-Trevino (Author), Mark E. Cooper (Author), Rhian M. Touyz (Author), Christopher R. J. Kennedy (Author), Jay C. Jha (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic hyperglycemia induces intrarenal oxidative stress due to the excessive production of reactive oxygen species (ROS), leading to a cascade of events that contribute to the development and progression of diabetic kidney disease (DKD). NOX5, a pro-oxidant NADPH oxidase isoform, has been identifi...