Endothelial NOX5 Obliterates the Reno-Protective Effect of Nox4 Deletion by Promoting Renal Fibrosis via Activation of EMT and ROS-Sensitive Pathways in Diabetes

• Päätekijät: Karin A. M. Jandeleit-Dahm (Tekijä), Haritha R. Kankanamalage (Tekijä), Aozhi Dai (Tekijä), Jaroslawna Meister (Tekijä), Sara Lopez-Trevino (Tekijä), Mark E. Cooper (Tekijä), Rhian M. Touyz (Tekijä), Christopher R. J. Kennedy (Tekijä), Jay C. Jha (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2024-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Chronic hyperglycemia induces intrarenal oxidative stress due to the excessive production of reactive oxygen species (ROS), leading to a cascade of events that contribute to the development and progression of diabetic kidney disease (DKD). NOX5, a pro-oxidant NADPH oxidase isoform, has been identifi...