KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins

• Main Authors: Laura Cianfruglia (Author), Andrea Perrelli (Author), Claudia Fornelli (Author), Alessandro Magini (Author), Stefania Gorbi (Author), Anna Maria Salzano (Author), Cinzia Antognelli (Author), Francesca Retta (Author), Valerio Benedetti (Author), Paola Cassoni (Author), Carla Emiliani (Author), Giovanni Principato (Author), Andrea Scaloni (Author), Tatiana Armeni (Author), Saverio Francesco Retta (Author)
• Format: Book
• Published: MDPI AG, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loss-of-function mutations in the KRIT1 gene are associated with the pathogenesis of cerebral cavernous malformations (CCMs), a major cerebrovascular disease still awaiting therapies. Accumulating evidence demonstrates that KRIT1 plays an important role in major redox-sensitive mechanisms, including...