Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain

• Main Authors: Tsuda Makoto (Author), Uchida Takahiro (Author), Yoshida Miyako (Author), Matsunaga Naoya (Author), Hamamura Kengo (Author), Koyanagi Satoru (Author), Kusunose Naoki (Author), Inoue Kazuhide (Author), Ohdo Shigehiro (Author)
• Format: Book
• Published: SAGE Publishing, 2010-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Neuropathic pain is characterized by hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to NSAIDs or even opioids. Gabapentin, a GABA analogue, was originally developed to treat epilepsy. Accumu...