Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor

• Main Authors: Dwi U Kemaladewi (Author), Svitlana Pasteuning (Author), Joke W van der Meulen (Author), Sandra H van Heiningen (Author), Gert-Jan van Ommen (Author), Peter ten Dijke (Author), Annemieke Aartsma-Rus (Author), Peter AC 't Hoen (Author), Willem M Hoogaars (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Duchenne muscular dystrophy (DMD) is caused by lack of functional dystrophin and results in progressive myofiber damage and degeneration. In addition, impaired muscle regeneration and fibrosis contribute to the progressive pathology of DMD. Importantly, transforming growth factor-β (TGF-β) is implic...