Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects

• Main Authors: Masaya Tachibana (Author), Shunji Matsuki (Author), Yutaro Maekawa (Author), Kana Kuroda (Author), Takako Shimizu (Author), Junko Tsutsumi (Author), Hitoshi Ishizuka (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors. Itraconazole and fluconazole are antifungal medications often used...