Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects

• Glavni autori: Masaya Tachibana (Autor), Shunji Matsuki (Autor), Yutaro Maekawa (Autor), Kana Kuroda (Autor), Takako Shimizu (Autor), Junko Tsutsumi (Autor), Hitoshi Ishizuka (Autor)
• Format: Knjiga
• Izdano: Wiley, 2023-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors. Itraconazole and fluconazole are antifungal medications often used...