Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

• Autores principales: Timothy B. C. Johnstone (Autor), Hilary S. McCarren (Autor), Jay Spampanato (Autor), F. Edward Dudek (Autor), John H. McDonough (Autor), Derk Hogenkamp (Autor), Kelvin W. Gee (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE). Extrasynaptic GABAARs, such as those containing α4β3δ s...