Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose

• 主要な著者: Giulia Frapporti (著者), Eleonora Colombo (著者), Hazem Ahmed (著者), Giulia Assoni (著者), Laura Polito (著者), Pietro Randazzo (著者), Daniela Arosio (著者), Pierfausto Seneci (著者), Giovanni Piccoli (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The disaccharide trehalose is a well-established autophagy inducer, but its therapeutic application is severely hampered by its low potency and poor pharmacokinetic profile. Thus, we targeted the rational design and synthesis of trehalose-based small molecules and nano objects to overcome such issue...