Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose

• Váldodahkkit: Giulia Frapporti (Dahkki), Eleonora Colombo (Dahkki), Hazem Ahmed (Dahkki), Giulia Assoni (Dahkki), Laura Polito (Dahkki), Pietro Randazzo (Dahkki), Daniela Arosio (Dahkki), Pierfausto Seneci (Dahkki), Giovanni Piccoli (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-04-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The disaccharide trehalose is a well-established autophagy inducer, but its therapeutic application is severely hampered by its low potency and poor pharmacokinetic profile. Thus, we targeted the rational design and synthesis of trehalose-based small molecules and nano objects to overcome such issue...