Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose

• Main Authors: Giulia Frapporti (Author), Eleonora Colombo (Author), Hazem Ahmed (Author), Giulia Assoni (Author), Laura Polito (Author), Pietro Randazzo (Author), Daniela Arosio (Author), Pierfausto Seneci (Author), Giovanni Piccoli (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The disaccharide trehalose is a well-established autophagy inducer, but its therapeutic application is severely hampered by its low potency and poor pharmacokinetic profile. Thus, we targeted the rational design and synthesis of trehalose-based small molecules and nano objects to overcome such issue...