An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T)

Background: ATM, the protein defective in the human genetic disorder, ataxia-telangiectasia (A-T) plays a central role in response to DNA double-strand breaks (DSBs) and in protecting the cell against oxidative stress. We showed that A-T cells are hypersensitive to metabolic stress which can be acco...

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Main Authors: A.J. Yeo (Author), G.N. Subramanian (Author), K.L. Chong (Author), M. Gatei (Author), R.G. Parton (Author), D. Coman (Author), M.F. Lavin (Author)
Formato: Livro
Publicado em: Elsevier, 2021-12-01T00:00:00Z.
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