An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T)

• Egile Nagusiak: A.J. Yeo (Egilea), G.N. Subramanian (Egilea), K.L. Chong (Egilea), M. Gatei (Egilea), R.G. Parton (Egilea), D. Coman (Egilea), M.F. Lavin (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2021-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background: ATM, the protein defective in the human genetic disorder, ataxia-telangiectasia (A-T) plays a central role in response to DNA double-strand breaks (DSBs) and in protecting the cell against oxidative stress. We showed that A-T cells are hypersensitive to metabolic stress which can be acco...