Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: I. Optimization, Characterization, Brain Localization, and Cytotoxic Studies

• Main Authors: Mohammed H. Elkomy (Author), Randa Mohammed Zaki (Author), Omar A. Alsaidan (Author), Mohammed Elmowafy (Author), Ameeduzzafar Zafar (Author), Khaled Shalaby (Author), Mohamed A. Abdelgawad (Author), Fatma I. Abo El-Ela (Author), Mostafa E. Rateb (Author), Ibrahim A. Naguib (Author), Hussein M. Eid (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Numerous neurological disorders have a pathophysiology that involves an increase in free radical production in the brain. Quercetin (QER) is a nutraceutical compound that shields the brain against oxidative stress-induced neurodegeneration. Nonetheless, its low oral bioavailability diminishes brain...