Formulation of a film-coated dutasteride tablet bioequivalent to a soft gelatin capsule (Avodart®): Effect of γ-cyclodextrin and solubilizers

• Główni autorzy: Mi-Hong Min (Autor), Jin-Hyong Park (Autor), Mi-Ran Choi (Autor), Jong-Hyun Hur (Autor), Byung-Nak Ahn (Autor), Dae-Duk Kim (Autor)
• Format: Książka
• Wydane: Elsevier, 2019-05-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The aim of this study was to optimize a tablet formulation of dutasteride that is bioequivalent to a commercially available soft gelatin capsule (Avodart®). The effect of cyclodextrin on enhancing the aqueous solubility of dutasteride was investigated, after which the formulation was further optimiz...