Formulation of a film-coated dutasteride tablet bioequivalent to a soft gelatin capsule (Avodart®): Effect of γ-cyclodextrin and solubilizers

• Váldodahkkit: Mi-Hong Min (Dahkki), Jin-Hyong Park (Dahkki), Mi-Ran Choi (Dahkki), Jong-Hyun Hur (Dahkki), Byung-Nak Ahn (Dahkki), Dae-Duk Kim (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2019-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The aim of this study was to optimize a tablet formulation of dutasteride that is bioequivalent to a commercially available soft gelatin capsule (Avodart®). The effect of cyclodextrin on enhancing the aqueous solubility of dutasteride was investigated, after which the formulation was further optimiz...