Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice

• Main Authors: Jing Xue (Author), Yu Cheng (Author), Haojie Hao (Author), Jieqing Gao (Author), Yaqi Yin (Author), Songyan Yu (Author), Junyan Zou (Author), Jiejie Liu (Author), Qi Zhang (Author), Yiming Mu (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Progressive β-cell dysfunction, a major characteristic of type 2 diabetes (T2D), is closely related to the infiltration of inflammatory macrophages within islets. Mesenchymal stem cells (MSCs) have been identified to alleviate β-cell dysfunction by modulating macrophage phenotype in T2D,...