Pharmacokinetic Study of Oral 14C-Radiolabeled Hyzetimibe, A New Cholesterol Absorption Inhibitor

• المؤلفون الرئيسيون: Jianwei Liao (مؤلف), Xin Wang (مؤلف), Zhenyu Li (مؤلف), Dongsheng Ouyang (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background and objectives: Hyzetimibe is a candidate drug being investigated as the second-in-class cholesterol absorption inhibitor; it lowers plasma levels of low-density lipoprotein cholesterol (LDL-C) by blocking the Niemann-Pick C1-like 1 protein, a transporter mainly expressed in the intestine...