BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer

• Main Authors: Nan Liu (Author), Shuai Wang (Author), Munan Li (Author), Nan Zhao (Author), Deyu Wang (Author), Rui Zhang (Author), Mingxin Yu (Author), Luoyi Zhao (Author), Siwei Zhang (Author), Fangbin Han (Author), Ying Zhao (Author), Quan Liu (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bromodomain and extraterminal domain (BET) family proteins serve as primary readers of acetylated lysine residues and play crucial roles in cell proliferation and differentiation. Dysregulation of BET proteins has been implicated in tumorigenesis, making them important therapeutic targets. BET-b...