BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer

• Главные авторы: Nan Liu (Автор), Shuai Wang (Автор), Munan Li (Автор), Nan Zhao (Автор), Deyu Wang (Автор), Rui Zhang (Автор), Mingxin Yu (Автор), Luoyi Zhao (Автор), Siwei Zhang (Автор), Fangbin Han (Автор), Ying Zhao (Автор), Quan Liu (Автор)
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• Опубликовано: Elsevier, 2024-10-01T00:00:00Z.
• Предметы: article
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The bromodomain and extraterminal domain (BET) family proteins serve as primary readers of acetylated lysine residues and play crucial roles in cell proliferation and differentiation. Dysregulation of BET proteins has been implicated in tumorigenesis, making them important therapeutic targets. BET-b...