Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines

• Main Authors: Niku Moni Das (Author), Biswa Mohan Prusty (Author), Nirmalya Pradhan (Author), Anjali Gupta (Author), Miguel Carmena-Bargueño (Author), Rama Karn (Author), Horacio Pérez-Sánchez (Author), Sachin Kumar (Author), Debasis Manna (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, we report the development of synthetically simpler analogs of 4,7-dichloroquinoline (DCQ) as apo-indoleamine 2,3-dioxygenase 1(IDO1) protein targeting ligand to inhibit the activity of IDO1 enzyme. Derivatization of the DCQ moiety improved the IDO1 inhibitory activity both against purified e...