Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

• Main Authors: Emma Rose McGlone (Author), Yusman Manchanda (Author), Ben Jones (Author), Phil Pickford (Author), Asuka Inoue (Author), David Carling (Author), Stephen R. Bloom (Author), Tricia Tan (Author), Alejandra Tomas (Author)
• Formato: Livro
• Publicado em: Elsevier, 2021-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objectives: Receptor Activity-Modifying Protein 2 (RAMP2) is a chaperone protein which allosterically binds to and interacts with the glucagon receptor (GCGR). The aims of this study were to investigate the effects of RAMP2 on GCGR trafficking and signalling in the liver, where glucagon (GCG) is imp...