LRRK2 Inhibition by PF06447475 Antagonist Modulates Early Neuronal Damage after Spinal Cord Trauma

• Asıl Yazarlar: Alessia Filippone (Yazar), Deborah Mannino (Yazar), Laura Cucinotta (Yazar), Irene Paterniti (Yazar), Emanuela Esposito (Yazar), Michela Campolo (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Spinal cord injury (SCI) is a devastating event followed by neurodegeneration, activation of the inflammatory cascade, and immune system. The leucine-rich-repeat kinase 2 (LRRK2) is a gene associated with Parkinson's disease (PD), moreover, its kinase activity was found to be upregulated after...