Activation of Piezo1 or TRPV2 channels inhibits human ureteral contractions via NO release from the mucosa

• Main Authors: Jianing Liu (Author), Cong Wang (Author), Wenyu Wang (Author), Ning Ding (Author), Jiaxin Liu (Author), Hanwen Liu (Author), Jiliang Wen (Author), Wendong Sun (Author), Shulu Zu (Author), Xiulin Zhang (Author), Jieke Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We aimed to investigate the expression and motor modulatory roles of several mechano-sensitive channels (MSCs) in human ureter. Human proximal ureters were obtained from eighty patients subjected to nephrectomy. Expression of MSCs at mRNA, protein and functional levels were examined. Contractions of...