Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

• Main Authors: Hao Shi (Author), Alexander Munk (Author), Thomas S. Nielsen (Author), Morgan R. Daughtry (Author), Louise Larsson (Author), Shize Li (Author), Kasper F. Høyer (Author), Hannah W. Geisler (Author), Karolina Sulek (Author), Rasmus Kjøbsted (Author), Taylor Fisher (Author), Marianne M. Andersen (Author), Zhengxing Shen (Author), Ulrik K. Hansen (Author), Eric M. England (Author), Zhiyong Cheng (Author), Kurt Højlund (Author), Jørgen F.P. Wojtaszewski (Author), Xiaoyong Yang (Author), Matthew W. Hulver (Author), Richard F. Helm (Author), Jonas T. Treebak (Author), David E. Gerrard (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Given that cellular O-GlcNAcylation levels are thought to be real-time measures of cellular nutrient status and dysregulated O-GlcNAc signaling is associated with insulin resistance, we evaluated the role of O-GlcNAc transferase (OGT), the enzyme that mediates O-GlcNAcylation, in skeletal...