Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney

• Main Authors: Elia Escasany (Author), Borja Lanzón (Author), Almudena García-Carrasco (Author), Adriana Izquierdo-Lahuerta (Author), Lucía Torres (Author), Patricia Corrales (Author), Ana Elena Rodríguez Rodríguez (Author), Sergio Luis-Lima (Author), Concepción Martínez Álvarez (Author), Francisco Javier Ruperez (Author), Manuel Ros (Author), Esteban Porrini (Author), Mikael Rydén (Author), Gema Medina-Gómez (Author)
• Format: Book
• Published: The Company of Biologists, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glomerulosclerosis and tubulointerstitial fibrosis are pathological features of chronic kidney disease. Transforming growth factor β (TGFβ) is a key player in the development of fibrosis. However, of the three known TGFβ isoforms, only TGFβ1 has an established role in fibrosis, and the pathophysiolo...