Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)

• Main Authors: Xueqin Huang (Author), Li You (Author), Eugenie Nepovimova (Author), Miroslav Psotka (Author), David Malinak (Author), Marian Valko (Author), Ladislav Sivak (Author), Jan Korabecny (Author), Zbynek Heger (Author), Vojtech Adam (Author), Qinghua Wu (Author), Kamil Kuca (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair. Dysfunction of PIKK members and aberrant stimulation of the PI3K/AKT/mTOR signalling pathway are...