Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing

• Main Authors: Young-Jung Kim (Author), Ji-Young Yoo (Author), Ok-Soon Kim (Author), Han-byeol Kim (Author), Junghwa Ryu (Author), Hye-Sun Kim (Author), Jun-Ho Lee (Author), Hong-Il Yoo (Author), Dae-Yong Song (Author), Tai-Kyoung Baik (Author), Ran-Sook Woo (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The amyloid precursor protein (APP) is a key molecule in Alzheimer's disease. The prevailing view is that APP is initially transported to the plasma membrane as a full-length protein. Its localization at the cell surface can trigger downstream signaling and APP cleavage. Our previous work has s...