Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing

• Автори: Young-Jung Kim (Автор), Ji-Young Yoo (Автор), Ok-Soon Kim (Автор), Han-byeol Kim (Автор), Junghwa Ryu (Автор), Hye-Sun Kim (Автор), Jun-Ho Lee (Автор), Hong-Il Yoo (Автор), Dae-Yong Song (Автор), Tai-Kyoung Baik (Автор), Ran-Sook Woo (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2018-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The amyloid precursor protein (APP) is a key molecule in Alzheimer's disease. The prevailing view is that APP is initially transported to the plasma membrane as a full-length protein. Its localization at the cell surface can trigger downstream signaling and APP cleavage. Our previous work has s...