Characterization of LY2775240, a selective phosphodiesterase‐4 inhibitor, in nonclinical models and in healthy subjects

• Hoofdauteurs: Dipak R. Patel (Auteur), Shweta Urva (Auteur), Stephen Ho (Auteur), Cody J. Buckman (Auteur), Yanfei Ma (Auteur), Jean Lim (Auteur), Sean E. Sissons (Auteur), Mary S. Zuniga (Auteur), Diane Philips (Auteur), Karen Cox (Auteur), Daniel J. Dairaghi (Auteur)
• Formaat: Boek
• Gepubliceerd in: Wiley, 2021-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract LY2775240 is a highly selective, potent and orally‐administered inhibitor of phosphodiesterase 4 (PDE4), and is being investigated as a treatment option for inflammatory disorders, such as psoriasis. LY2775240 was investigated in rodent and rhesus monkey nonclinical models. Treatment with L...